Biochem/physiol Actions

Reversible: no

Product competes with ATP.

Target IC₅₀: 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH

Primary TargetSoluble epoxide hydrolase

Cell permeable: yes

General description

A cell-permeable 1,3-disubstituted urea compound that displays anti-hypertensive and anti-inflammatory properties. Acts as a potent, selective, competitive, and tight-binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH; IC₅₀ = 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH). Reported to decrease human VSMC (vascular smooth muscle cell) proliferation.

A cell-permeable, potent, selective, competitive, and tight binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH) (IC₅₀ = 9.8 nM for recombinant murine sEH and 85.2 nM for recombinant human sEH). Also displays anti-hypertensive and anti-inflammatory properties. Reported to decrease human vascular smmoth muscle cell (VSMC) proliferation.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Newman, J.W., et al. 2003. Proc. Natl. Acad. Sci. USA100, 1558.Davis, B.B., et al. 2002. Proc. Natl. Acad. Sci. USA99, 2222.Morisseau, C., et al. 2002. Biochem. Pharmacol.63, 1599.Imig, J.D., et al. 2002. Hypertension39, 690.Argiriadi, M.A., et al. 2000. J. Biol. Chem.275, 15265.Yu, Z., et al. 2000. Circ. Res.87, 992.

Packaging

Packaged under inert gas

25 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)